http://arxiv.org/abs/2108.05824
Brain organoids recapitulate a number of brain properties, including neuronal diversity. However, do they recapitulate brain shape? Using a hydrodynamic description for cell nuclei as particles interacting via an attractive field generated by the surrounding active cell cytoskeleton, we quantify shape development in brain organoids. Regions of cell nuclei overdensity in the linear regime drive the initial seeding for cortex-core structures, which emerge in the non-linear regime with elongated cell nuclei and thus, cell shape, in the cortex. We then use an extended version of the buckling without bending morphogenesis model to predict foliations/folds of the cortex in the presence of a nonlinearity due to elongated cells actively regulating strain. In addition to laying new groundwork for the design of more familiar and less familiar brain shapes, our work provides an intriguing quantitative connection with large-scale structure formation in the universe.
A. Borzou and J. Schwarz
Fri, 13 Aug 21
49/64
Comments: 14 pages, 9 figures. Comments are welcome
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